Doctor en Bioquímica Física // PhD in Biophysical Chemistry
Licenciado en Biotecnología // B.S. in Biotechnology
Investigador Adjunto (CONICET) // Research Associate (CONICET)
Profesor Adjunto // Associate Professor
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Pablo J. González se graduó en Licenciatura en Biotecnología por la Universidad Nacional del Litoral. Realizó su doctorado (PhD) en Bioquímica Física, en el Departamento de Química de la Faculdade de Ciencias y Tecnologia de la Universidade Nova de Lisboa (Portugal). Además, realizó posdoctorado en técnicas biofísicas aplicadas al estudio de metaloenzimas y luego fue contratado como investigador científico (Investigador Asistente) por el laboratorio asociado REQUIMTE (FCT-UNL, Portugal). En la actualidad, es Profesor Adjunto e Investigador científico (Investigador Adjunto - CONICET) en el Departamento de Física de la Facultad de Bioquímica y Ciencias Biológicas de la Universidad Nacional del Litoral, Argentina.
Pablo J. González received BSc degree on Biotechnology from Universidad Nacional del Litoral and PhD degree in Biophysical Chemistry in the Chemistry Department of the Faculdade de Ciências e Tecnologia at Universidade Nova de Lisboa (Portugal). He had postdoctoral training in biophysical techniques applied to the study of metalloenzymes before joining as a Research Scientist to REQUIMTE at FCT-UNL (Portugal). At present, he is a Professor and Research Scientist (CONICET) in the Physics Department at the Facultad de Bioquímica y Ciencias Biológicas of Universidad Nacional del Litoral, Argentina.
Publicaciones (últimos 5 años) // Papers (Last 5 years)
21- Substrate-dependent modulation of the enzymatic catalytic activity: reduction of nitrate, chlorate and perchlorate by respiratory nitrate reductase from Marinobacter hydrocarbonoclasticus 617. Marangon J, Paes de Sousa PM, Moura I, Brondino CD, Moura JJG and González PJ*. BBA-Bioenergetics 2012, 1817: 1072–1082.
22- Periplasmic nitrate reductases and formate dehydrogenases: Biological control of the chemical properties of Mo and W for fine tuning of reactivity, substrate specificity and metabolic role. Gonzalez PJ*, Rivas MG, Mota CS, Brondino CD, Moura I, Moura JJG. Coord Chem Rev 2013, 257(2), 315-331.
23- The Sulfur Shift: An Activation Mechanism for Periplasmic Nitrate Reductase and Formate Dehydrogenase. Cerqueira NMFSA*, Fernandes PA, González PJ, Moura JJG, Ramos MJ. Inorg Chem 2013, 52 (19) 10766–10772.
24- Kinetic and Structural Studies of Aldehyde Oxidoreductase from Desulfovibrio gigas reveal a Dithiolene-Based Chemistry for Enzyme Activation and Inhibition by H2O2. Marangon J, Correia HD, Brondino CD, Moura JJG, Romão MJ, González PJ*, Santos-Silva T*. PloS-One 2013. e83234. doi:10.1371/journal.pone.0083234.
25- Copper(ii) complexes of bis(aryl-imino)acenaphthene ligands: Synthesis, structure, DFT studies and evaluation in reverse ATRP of styrene. Fliedel C, Rosa V, Santos CIM, Gonzalez PJ, Almeida RM, Gomes CSB, Gomes PT, Lemos MANDA, Aullón G, Welter R, Avilés T. Dalton Transactions 2014, 43(34) 13041-13054.
26- Aromatic aldehydes at the active site of Aldehyde Oxidoreductase from Desulfovibrio gigas: Reactivity and Molecular Details of the Enzyme-Substrate and Enzyme-Product Interaction. Correia HD, Marangon J, Brondino CD, Moura JJG, Romão MJ, González PJ* and Santos-Silva T*. J Biol Inorg Chem 2015, 20:219-229.
27- Isotropic exchange interaction between Mo and the proximal FeS center in the xanthine oxidase family member aldehyde oxidoreductase from Desulfovibrio gigas on native and polyalcohol inhibited samples: an EPR and QM/MM study. Gómez MC, Neuman NI, Dalosto SD, González PJ, Moura JJG, Rizzi AC, Brondino CD*. J Biol Inorg Chem 2015, 20:233-242.
28- The homopentameric chlorite dismutase from Magnetospirillum sp. Freire DM, Rivas MG, Dias AM, Lopes AT, Costa C, Santos-Silva T, Van Doorslaer S*, González PJ*. J Inorg Biochem 2015, 151: 1-9.
29- Ligand Binding to Chlorite Dismutase from Magnetospirillum sp. De Schutter A, Correia HD, Freire DM, Rivas MG, Rizzi A, Santos-Silva T, González PJ*, Van Doorslaer S*. J Phys Chem-B 2015, 119(43): 13859-13869.
30- Periplasmic Nitrate Reductase and Formate Dehydrogenase: Similar Molecular Architectures with Very Different Enzymatic Activities. Cerqueira NMFSA, Gonzalez PJ, Fernandes PA, Moura JJG, Ramos MJ. Acc. Chem. Res. 2015, 48(11): 2875-2884.
31- EPR as a Tool to Study Isolated and Coupled Paramagnetic Centers in Coordination Compounds and Macromolecules of Biological Interest. Rizzi AC, Neuman NI, González PJ, Brondino CD. Eur J Inorg Chem 2016, 2016(2): 187-207.
Capítulos de Libro // Book Chapters
1- Dissimilatory nitrate and nitrite ammonification by sulphate-reducing eubacteria. José J.G. Moura, Pablo J. González, Isabel Moura and Guy Fauque. Barton & Hamilton. Sulphate-Reducing Bacteria: Environmental and Engineered Systems, Eds. Barton and Hamilton, Cambridge Univ. Press, 2007.
2- Structure, Function and Mechanisms of Respiratory Nitrate Reductases. Pablo J. Gonzalez, Maria G. Rivas and Jose J.G. Moura. Metalloenzymes in Denitrification: Applications and Environmental Impacts, Eds. Moura, Moura, Pauleta & Maia, RSC Metalobiology, Cambridge, 2017